Malignant mesothelioma in the chest or the visceral or parietal pleura derived. Although rare, they have assumed great importance in recent years due to its higher incidence in people with high exposure to asbestos. In coastal areas with maritime industries in the United States and Great Britain and in the mining areas of Canada and South Africa, up to 90% of reported mesotheliomas are asbestos-related. There is a long period of 25 to 45 years for the development of asbestos-related mesothelioma and there seems to be an increased risk of mesothelioma asbestos workers who smoke. This is in contrast to the risk of lung cancer related to asbestos already high and is significantly increased by smoking. Sun asbestos workers who smoke even exceed) the risk of dying from lung cancer by far, the development of mesothelioma.
Asbestos found in greater numbers in the lungs of patients with mesothelioma and mesothelioma can be easily induced in experimental animals by intrapleural injection of asbestos.
Malignant mesothelioma is a diffuse lesion that is widely spread in the pleural space and is usually associated with extensive pleural effusion and the direct invasion of the thoracic structures. The affected lung is sheathed by a thick layer of soft tissue gelatinous, pink-gray tumor.
Microscopically malignant mesothelioma consists of a mixture of two types of cells either one of which may predominate in an individual case. Mesothelial cells have the potential to develop into mesenchymal or stromal cells or epithelial cells lining like. The latter is the usual form of the mesothelium, epithelium lining the major body cavities. Mesenchymal mesothelioma types appears as a fibrosarcoma-like spindle cell sarcoma (sarcomatoid type), while the papillary type is composed of columns cubic or flattened cells forming tubular and papillary structures (epithelial type) adenocarcinoma similar. Epithelial mesothelioma can sometimes be difficult to differentiate grossly and histologically in lung adenocarcinoma. The special features that promote mesothelioma include the following (1) positive staining for acid mucopolysaccharide, which is inhibited by prior digestion with hyaluronidase, (2) the lack of staining for carcinoembryonic antigen (CFA) and other epithelial glycoprotein antigen , markers generally expressed by adenocarcinoma (3) strong staining for keratin proteins with accentuation of perinuclear staining rather than peripheral (4) electron microscopy the presence of long microvilli and abundant tonofilaments but in the absence of rootletsmicrovilli and lamellar bodies. The mixed type of mesothelioma contains epithelial and sarcomatoid patterns. Cytogenetic abnormalities occur in cases of mesothelioma, but not reactive mesothelial proliferations a useful feature for diagnosis.
Clinical course
Presenting complaints are chest pain, dyspnea, and as noted recurrent pleural effusions. Concurrent pulmonary asbestosis (fibrosis) is present in only 20% of patients with pleural mesothelioma. Fifty percent of people with pleural disease die within 12 months after diagnosis and few survive more than 2 years. Aggressive therapy (extrapleural pneumonectomy, chemotherapy, radiotherapy) appears to improve the poor prognosis in some patients. The lung is invaded directly, and often has metastasized to the hilar lymph nodes and, finally, liver and distant organs.
Mesotheliomas in the peritoneum, pericardium, and tunica vaginalis andgenital tract arise. Peritoneal mesothelioma most serious asbestos exposure, 50% of these patients also have pulmonary fibrosis. Although about 50% of the cases of the disease remains confinedto the cavity abnorminal, bowel involvement often leads to death by starvation or bowel obstruction.
For more information: http://mesoblog.org/blog/
Asbestos found in greater numbers in the lungs of patients with mesothelioma and mesothelioma can be easily induced in experimental animals by intrapleural injection of asbestos.
Malignant mesothelioma is a diffuse lesion that is widely spread in the pleural space and is usually associated with extensive pleural effusion and the direct invasion of the thoracic structures. The affected lung is sheathed by a thick layer of soft tissue gelatinous, pink-gray tumor.
Microscopically malignant mesothelioma consists of a mixture of two types of cells either one of which may predominate in an individual case. Mesothelial cells have the potential to develop into mesenchymal or stromal cells or epithelial cells lining like. The latter is the usual form of the mesothelium, epithelium lining the major body cavities. Mesenchymal mesothelioma types appears as a fibrosarcoma-like spindle cell sarcoma (sarcomatoid type), while the papillary type is composed of columns cubic or flattened cells forming tubular and papillary structures (epithelial type) adenocarcinoma similar. Epithelial mesothelioma can sometimes be difficult to differentiate grossly and histologically in lung adenocarcinoma. The special features that promote mesothelioma include the following (1) positive staining for acid mucopolysaccharide, which is inhibited by prior digestion with hyaluronidase, (2) the lack of staining for carcinoembryonic antigen (CFA) and other epithelial glycoprotein antigen , markers generally expressed by adenocarcinoma (3) strong staining for keratin proteins with accentuation of perinuclear staining rather than peripheral (4) electron microscopy the presence of long microvilli and abundant tonofilaments but in the absence of rootletsmicrovilli and lamellar bodies. The mixed type of mesothelioma contains epithelial and sarcomatoid patterns. Cytogenetic abnormalities occur in cases of mesothelioma, but not reactive mesothelial proliferations a useful feature for diagnosis.
Clinical course
Presenting complaints are chest pain, dyspnea, and as noted recurrent pleural effusions. Concurrent pulmonary asbestosis (fibrosis) is present in only 20% of patients with pleural mesothelioma. Fifty percent of people with pleural disease die within 12 months after diagnosis and few survive more than 2 years. Aggressive therapy (extrapleural pneumonectomy, chemotherapy, radiotherapy) appears to improve the poor prognosis in some patients. The lung is invaded directly, and often has metastasized to the hilar lymph nodes and, finally, liver and distant organs.
Mesotheliomas in the peritoneum, pericardium, and tunica vaginalis andgenital tract arise. Peritoneal mesothelioma most serious asbestos exposure, 50% of these patients also have pulmonary fibrosis. Although about 50% of the cases of the disease remains confinedto the cavity abnorminal, bowel involvement often leads to death by starvation or bowel obstruction.
For more information: http://mesoblog.org/blog/
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